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Health

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ACPN to FG: Use pharmacies to decongest hospitals

The Association of Community Pharmacists of Nigeria (ACPN) has urged the Federal Government to deploy community pharmacies as strategic frontline healthcare providers to improve access to care and help decongest secondary and tertiary hospitals. The association also called for government investment in the Pharmacy First Initiative (PFI), saying the model could accelerate Universal Health Coverage [...] The post ACPN to FG: Use pharmacies to decongest hospitals appeared first on Tribune Online .

Tribune·12h ago·1m
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Using your phone while pregnant may not be as safe as we thought

Decades of studies on the health impacts of cell phones have consistently found little cause for concern for most of us. Yet one demographic may still have some reason to restrict their doom-scrolling and YouTube watching – pregnant mothers. Continue Reading Category: Heart Disease , Illnesses and conditions , Body and Mind Tags: Cell+Phone , Pregnancy , Cardiovascular , Baby , Radiation , Radio Waves

New Atlas·12h ago·1m
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PsychAD studies map molecular mechanisms across major brain disorders

Research led by Mount Sinai scientists within the PsychAD Consortium, a large-scale, multidisciplinary initiative launched in 2019 with support from the National Institute on Aging (NIA), is featured in a landmark collection of nine papers published across the Nature family of journals that maps the molecular mechanisms underlying Alzheimer's disease, Parkinson's disease, schizophrenia, and other brain disorders.

News-Medical·12h ago·1m
Trending

Distinct immune inflammatory markers and proteomic signatures underlying psoriasis with pruritus

Pruritus is a common and burdensome symptom in patients with psoriasis, yet its underlying systemic mechanisms are not sufficiently defined. To characterize systemic immune-inflammatory profiles and serum proteomic differences associated with pruritus in patients with psoriasis and identify potential biomarkers linked to pruritus. Serum immune-inflammatory markers from 267 psoriasis patients were analyzed. Proteomic profiling was performed by mass spectrometry in pruritic psoriasis (n = 8), non-pruritic psoriasis (n = 5), and healthy controls (n = 3). Pruritic psoriasis patients tended to be younger with shorter disease duration, while other clinical characteristics were comparable. Total IgE tended to be higher in pruritic psoriasis, particularly in moderate-to-severe cases. The eosinophil-to-lymphocyte ratio (ELR) was significantly elevated in pruritic psoriasis, whereas other inflammatory indices did not differ. Proteomic analysis revealed distinct clustering of pruritic psoriasis from non-pruritic psoriasis and healthy controls, with enrichment of complement activation, coagulation, and fibrinolysis. Compared with non-pruritic psoriasis, pruritic psoriasis additionally showed upregulation of actin cytoskeletal organization, wound healing proteins, and transient receptor potential melastatin 2 (TRPM2). Pruritic psoriasis is characterized by elevated ELR and distinct proteomic signatures involving complement activation, coagulation, tissue remodeling, and TRPM2 upregulation, implicating these pathways in the mechanisms underlying psoriatic pruritus.

Nature·12h ago·1m
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